The epidemiology of drug-induced severe skin reactions accounts for 30% total of the world’s population. The Drugs such as NSAIDs, antibiotics, allopurinol, phenytoin, calcium channel blockers, cimetidine, quinidine, carbamazepine, gold, are mostly identified reported and are concerned with causing of drug-induced erythroderma which represents the inflammatory condition of the skin resulting with scaling and erythema which in turn affects more than 90% of the body surface. In the present case report, a male patient aged 77 years old with a weight of 52kg was admitted to department of DVI, Sai Siddartha Multi Speciality Hospital, Kakinada, Andhra Pradesh, India. Complaining about symptoms like itchy skin lesions over body since one month and describing his present illness as the rash developed over the trunk and later has been spread to other parts of his body. He further represented the past medical history such as he was diagnosed with pulmonary tuberculosis and was on antitubercular drug therapy with oral 300mg of Isoniazid. Based on the laboratory investigations and as well as based on the WHO-UMC causality ADR assessments information the case was undergone to a confirmatory diagnosis of drug-induced erythroderma which may be probably due to antitubercular drug usage.
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